Actually, I think things are fine (though there may be a bug in Isaac).
1. It looks like you're not on profile 4; I say this because it looks like your HR data is being shown, not your CdA data
2. There is a separate window called "Tools/Power Meter Comparison" which also calculates CdA. This window shows that your "out" CdA and "back" CdA are about the same.

- Power Meter Comparison with CdA = 0.296
- Screen Shot 2019-05-15 at 6.25.25 PM.png (136.63 KiB) Viewed 7531 times
It looked to me that your CdA was about 0.23, and when I used that number in the "Analyze/Tweak CdA..." screen

- Analyze CdA command
- Screen Shot 2019-05-15 at 6.27.33 PM.png (177.19 KiB) Viewed 7531 times

- Change CdA to 0.23
- Screen Shot 2019-05-15 at 6.28.08 PM.png (151.62 KiB) Viewed 7531 times
I got great results!

- Power Meter Comparison with CdA = 0.23
- Screen Shot 2019-05-15 at 6.28.46 PM.png (140.84 KiB) Viewed 7531 times
3. There may be a bug in the "CdA Analysis" window...we will check this.